ABSTRACT
Introduction: Self-medication is one of the most common health maintenance practices in the world, and has been observed more frequently after the emergence of the Covid-19 pandemic. In this context, responsible self-medication is very important to ensure public health and to alleviate health systems. Medical students are referents in society in terms of medication knowledge and therefore are promoters of medication use behaviors.Objective: evaluate self-medication practices among medical students in the context of non-specific symptoms associated or not with SARS-COV-2 infection at a university in Barranquilla, Colombia. Methods: Cross-sectional study conducted in a population of 2285 medical students. A sample of 350 randomly selected students was taken, and a self-administered survey was applied to inquire about aspects related to self-medication practices.Results: The prevalence of self-medication was 100%, and non-responsible self-medication practices were identified in 70.1% of the participants. The academic level of clinical sciences was associated with a high level of knowledge of medication (OR: 1.91;95%CI: 1.1-3.6);however, these variables did not show an association with responsible self-medication practices. Additionally, 48% indicated that they would be willing to self-medicate without seeking medical assistance in case of symptoms probably related to COVID-19. Conclusions: A high frequency of non-responsible self-medication was found. Further studies are needed to facilitate effective interventions.
ABSTRACT
Background and importanceBisphosphonates should be the first choice for osteoporosis treatment, with lower cost and no less benefit than denosumab.Aim and objectivesTo evaluate the indication for treatment with denosumab and to develop proposals for optimising osteoporosis treatment.Material and methodsCross-sectional study in a primary care area (8 centres). Data from the ECAP digital medical record of denosumab-treated patients during January 2020 were reviewed by the Pharmacy Service. Variables: demographic (age and sex), diagnosis, bone mineral density (BMD) and previous fractures, indication, previous treatment and adherence.ResultsA total of 394 denosumab-treated patients, aged 74.9 ± 9.6 years, 92.6% women, were included. BMD T-score was ≤–2.5 (indicative of osteoporosis) in 48.3% of men and 64.1% of women, while it was >–2.5 in 6.9% of men and 14.8% of women. There was no densitometric test in the remaining patients. The most prevalent previous fracture in men was hip fracture (31%), while previous fracture was not present in most women (49.6%). Other fractures in men: 27.6% none, 24.1% vertebral, 17.3% ≥2 vertebral. In women: 16.7% ≥2 vertebral, 13.7% vertebral, 13.4% hip, 6.6% peripheral. Therefore, 80.8% of patients actually suffered from osteoporosis, while 19.2% had no true diagnosis. Osteoporosis patients receiving denosumab without a clear indication were 47.1%. Some 63% received prior treatment and 72.6% were adherent. Regarding those with an indication, 54.9% were due to ≥2 previous vertebral or hip fractures, 21.3% to adverse effects or poor adherence to bisphosphonates, 7.9% to chronic corticosteroid therapy, 7.4% to incident hip fracture or increased risk of fracture with age between 65 and 70 years, 5% to digestive alteration that contraindicates the use of therapeutic alternatives, and finally 3.5% to glomerular filtration <35 mL/min/m2. Denosumab should be withdrawn in 22% of patients and it should be changed to bisphosphonate in 25.1%, thus leading to a theoretical €75 100 annual saving.Conclusion and relevanceDenosumab should be withdrawn or replaced in 47.1% of patients. The proposals of the clinical pharmacist contribute to safe drug use and health system efficiency. It would be necessary to know the final implementation of the proposals by rheumatologists, which were pending due to the COVID-19 pandemic.References and/or acknowledgementsConflict of interestNo conflict of interest